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When ferritin releases iron, the iron produced causes a process called lipid peroxidation

The SURMOUNT-1 trial showed 19.5% average body weight reduction on 10 mg injectable, and sublingual protocols targeting equivalent exposure aim for the same outcome

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Cells were maintained as a single-cell culture (no colony formation) on COAT-1 pre-coated 6-well tissue culture plates in the Cellartis DEF-CS Culture System (Takara Bio, Inc.) at 37C in a humidified incubator supplied with 5% CO2